![]() ![]() ![]() Disorders associated with mitochondrial dysfunction include autism, Parkinson’s disease, and cancer. The marker used in the GPL-TOX profile indicates mitochondrial dysfunction by monitoring a metabolite that is elevated in mitochondrial deficiency of cofactors such as NAD+, flavin-containing coenzymes, and Coenzyme Q10. #Great plains laboratory freeThe mitochondria also have several other important functions in the cell, including steroid synthesis, calcium regulation, free radical production, and the induction of apoptosis or programmed cell death, all of which are involved in the pathogenesis of numerous disorders. Mitochondria are important in all cells in the body, but are especially important to organs that utilize large amounts of energy, such as the muscles, heart, and brain. These mutations can result from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies. The GPL-TOX profile tests for Tiglylglycine (TG), one of the most specific markers for mitochondrial disorders resulting from mutations of mitochondrial DNA. William Shaw, Ph.D., Director of The Great Plains Laboratory is board-certified in both clinical chemistry and toxicology by the American Board of Clinical Chemistry. This panel offers you comprehensive testing to assess exposure to common environmental toxins and the damage that can be caused by this exposure, all at a great value, and all from one urine sample. GPL-TOX pairs perfectly with our Organic Acids Test (OAT) and our Glyphosate Test in the Enviro-TOX Panel. GPL-TOX also includes Tiglylglycine, a marker for mitochondrial damage, which is often seen in chronic toxic chemical exposure. GPL-TOX uses the power of advanced mass spectrometry (MS/MS), which is necessary to detect lower levels of certain genetic, mitochondrial, and toxic chemical markers that conventional mass spectrometry often misses. GPL-TOX screens for 173 different environmental pollutants using 18 different metabolites, all from a single urine sample. These mutations can be caused by exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies. This profile also includes Tiglylglycine (TG), a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA. As we have become more exposed to chemical-laden products and to toxic chemicals in food, air, and water, we have been confronted with an accelerating rate of chronic illnesses like cancer, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D, autoimmune disorders, Parkinson’s disease, and Alzheimer’s disease.īecause exposure to environmental pollutants has been linked to many chronic diseases, The Great Plains Laboratory has created GPL-TOX, a toxic non-metal chemical profile that screens for the presence of 173 different toxic chemicals including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile, and more. Our mission is to improve wellness outcomes for patients with chronic illnesses by providing the most accurate, reliable, and comprehensive biomedical analyses available, using the latest technology and proven techniques, and offering education to patients, families, and health care practitioners.GPL-TOX Profile (Toxic Non-Metal Chemicals) GENERALĮvery day, we are exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides, packaged foods, household products, and environmental pollution. Our laboratory provides the most reliable, comprehensive, and understandable scientific results, using the latest technology and proven techniques. We are dedicated to assisting healthcare practitioners make a difference by helping children, adults, and families achieve their maximum potential through quality laboratory testing. We provide a variety of metabolic tests including those for immune deficiency, amino acids, essential fatty acids, glutathione levels, inflammation, metal and non-metal chemical toxicity, mold toxicity, and food allergies. is a research-based clinical laboratory offering testing for nutritional factors in chronic illnesses such as autism, AD(H)D, fibromyalgia, and gastrointestinal and neuropsychiatric disorders. ![]()
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